Invited Speaker
Alexander Vologodskii, New York University, USA.
How Conformational Properties of Long DNA Molecules Depend on Their Topology?
Topology affects various conformational properties of long DNA molecules. In this presentation we address, first of all, the influence of topology on local properties of circular DNA molecules. These properties may be related to DNA topology simplification by type II DNA topoisomerases; since the enzymes can access only local properties of DNA coils. Using Monte Carlo simulation we addressed equilibrium properties of the molecules; dynamic properties were investigated by Brownian dynamics simulation. In both simulations DNA molecule was modeled by the discrete wormlike chain model. Numerous earlier studies had shown that the model provides accurate description of both equilibrium and dynamic properties of the double helix.