Invited Speaker
Julien Dorier and Andrzej Stasiak, (www.unil.ch/cig/page50667_en.html),
Rosa & Everares (1) recently proposed that formation of chromosomal territories is due to a kinetic effect connected to topological constraints encountered by decondensing chromosomes. Intrigued by (1), we used numerical simulations to investigate the effect of topoisomerase-mediated DNA-DNA passages on formation of chromosomal territories.
1. Rosa A, Everaers R (2008) Structure and Dynamics of Interphase Chromosomes. PLoS Comput Biol 4(8): e1000153.